Bone Marrow, Plasma cell neoplasm [LMP14553]

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Image Details
Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Neoplasia
Diagnosis: 
Plasma cell neoplasm
Species: 
Human
Organ System: 
White Blood Cells, Lymph Nodes, Spleen, and Thymus
Gender: 
Male
Age: 
78 years
Diagnosis Code: 
ICD-10: C90.0 | ICD-O: 9732/3
Slide Contributor Information
Nagaria, T., Mete, O.

Keywords

plasma cell neoplasm, multiple myeloma, plasmacytoma, plasma cell myeloma

Clinical History

78 year old male with lytic bone lesions in thoracic and lumbar vertebra.

Clinical Discussion

Clinical history of lytic bone lesions in the thoracic and lumbar vertebrae in the elderly should prompt high suspicion for plasma cell neoplasm. This slide shows highly cellular infiltrates that are predominantly plasmacytoid. The majority of the cells are with ample basophilic cytoplasm, perinuclear hof, round eccentric nuclei. Some show “clock face” chromatin and inconspicuous nucleoli.

These cells typically show CD138 (+), CD38 (+), CD79a (+), MUM1 (+), aberrant expression of CD56 (+), and light chain restriction. They also usually show negative staining for CD19 (-), CD20 (-), PAX5 (-), CD45 (-).