Brain, Clear cell meningioma [LMP67858]

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Diagnostic Modality: 
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Disease Category: 
Neoplasia
Diagnosis: 
Clear cell meningioma
Species: 
Human
Organ System: 
Central Nervous System
Gender: 
Male
Age: 
39 years
Diagnosis Code: 
ICD-10: D32.9 | ICD-O: 9538/1 
Slide Contributor Information
Gao, A., Munoz, D.

Keywords

meningioma, clear cell

Clinical History

39-year-old man with several-months history of headache, dizziness, hearing loss in the right ear with persistent tinnitus, facial numbness on the right, and diplopia. Neuroimaging shows right cerebello-pontine angle mass.

Clinical Discussion

Clear cell meningiomas are a rare variant of meningioma classified as WHO grade II. They typically present in younger patients, usually in the cerebello-pontine angle or cauda equina region. They are composed of polygonal cells with cytoplasmic clearing due to glycogen accumulation, which stains with PAS. Classic features of meningioma, such as whorls and psammoma bodies, are rare. Clear cell meningiomas behave more aggressively, with frequent recurrence and occasional CSF seeding.