Brain, IgG4-related hypophysitis [LMP33344]

LMP33344 Thumbnail
View the Zoomify Image
Image Details
Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Diseases of the Immune System
Diagnosis: 
IgG4-related hypophysitis
Species: 
Human
Organ System: 
Endocrine System
Gender: 
Male
Age: 
49 years
Diagnosis Code: 
ICD-10: M35.9
Slide Contributor Information
Gao, A., Munoz, D.

Keywords

IgG4, pituitary

Clinical History

49-year-old man with 3-year history of hypopituitarism and diabetes insipidus. Neuroimaging shows a sellar/suprasellar mass.

Clinical Discussion

IgG4-related hypophysitis is a presumed autoimmune disease of the pituitary gland that can occur in isolation or in the setting of systemic IgG4-related disease. Diagnostic histopathologic criteria for IgG4-related hypophysitis are lymphoplasmacytic infiltration of the pituitary gland with more than 10 IgG4-positive cells per high power field. IgG4-related disease is typically responsive to steroids but long term patient outcomes are still lacking.

Related Content

Related External Links: 
Leporati et al. IgG4-related hypophysitis: a new addition to the hypophysitis spectrum. J Clin Endocrinol Metab 2011;96...