Brain, Papillary tumour of the pineal region [LMP67622]

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Image Details
Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Neoplasia
Diagnosis: 
Papillary tumour of the pineal region
Species: 
Human
Organ System: 
Central Nervous System
Gender: 
Female
Age: 
30 years
Diagnosis Code: 
ICD-10: C75.3 | ICD-O: 9395/3
Slide Contributor Information
Gao, A., Keith, J.

Keywords

Pineal tumour, PTPR, subcommissural organ

Clinical History

30-year-old woman presents with blurred vision. Neuroimaging shows a tumour in the pineal region.

Clinical Discussion

Papillary tumour of the pineal region (PTPR) is a rare neuroepithelial neoplasm thought to arise from the subcommissural organ located in the posterior wall of the third ventricle at the entrance of the cerebral aqueduct. It typically occurs in adults and due to its location, it presents with CSF obstruction and hydrocephalus. Microscopically, PTPR has a papillary and/or solid architecture with epithelioid cells that may contain cytoplasmic vacuoles. Ependymal features (perivascular pseudorosettes, true rosettes) can be seen. Immunohistochemistry shows positivity for cytokeratins, S100, and focal and variable staining for GFAP. Prognosis is generally guarded and the biologic behaviour corresponds to WHO grade II or III but histologic grading criteria remain to be defined.