Brain, Pineocytoma [LMP90118]

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Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Neoplasia
Diagnosis: 
Pineocytoma
Species: 
Human
Organ System: 
Central Nervous System
Gender: 
Male
Age: 
32 years
Diagnosis Code: 
ICD-10: D44.5 | ICD-O: 9361/1
Slide Contributor Information
Gao, A., Munoz, D.

Keywords

pineal

Clinical History

32-year-old man with progressive headache. Neuroimaging shows 2 cm tumour in the pineal region.

Clinical Discussion

Pineocytomas are rare, slow-growing tumours arising in the pineal gland parenchyma and are classified as WHO grade I. They are well-circumscribed and composed of small, uniform cells resembling normal pineocytes arranged in sheets or lobules. Pineocytomatous rosettes, formed by cell nuclei surrounding a nucleus-free centre composed of fine cytoplasmic processes, can be seen. Immunohistochemistry shows reactivity for synaptophysin, neuron-specific enolase, and neurofilament. Prognosis is excellent and patients are potentially cured with gross total resection.