Breast, juvenile fibroadenoma [LMP78112]

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Image Details
Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Neoplasia
Diagnosis: 
Juvenile fibroadenoma
Species: 
Human
Organ System: 
Breast
Gender: 
Female
Age: 
17 years
Diagnosis Code: 
ICD-10: D24 | ICD-O: 9030/0
Slide Contributor Information
Wong, W., Chang, M.

Keywords

juvenile, fibroadenoma, breast, fibroepithelial

Clinical History

Breast mass in a 17 year old.

Clinical Discussion

Juvenile fibroadenoma of the breast is a tumour of adolescence characterized by rapid growth, and large size. Histologically it exhibits a biphasic (epithelial and stromal) pattern. It is characterized by hypercellular stroma and intraductal epithelial hyperplasia. It also commonly exhibits features in common with gynecomastoid hyperplasia, often distinguishing the juvenile-type from a conventional fibroadenoma, which has a canalicular-type architecture. Although the stroma can be cellular with scattered mitoses, the leaf-like architecture and peri-epithelial stromal condensation seen in phyllodes tumours are not present.