Colon, traditional serrated adenoma [LMP23919]

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Image Details
Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Neoplasia
Diagnosis: 
Traditional (sessile) serrated adenoma
Species: 
Human
Organ System: 
Gastrointestinal Tract
Gender: 
Male
Age: 
60 years
Diagnosis Code: 
ICD-10: D12.6 | ICD-O: 8213/0
Slide Contributor Information
Hosseini, N., Kirsch, R.

Keywords

sessile, serrated, adenomatous, polyp, colon

Clinical History

Colonic polyp (left-sided) seen during colonoscopy.

Clinical Discussion

Traditional (sessile) serrated adenomas (TSA) constitute <1% of serrated lesions and 1-2% colorectal adenomas. They are mostly found in the left colon and are sessile with villiform surface. This makes them difficult to differentiate from adenomatous polyps in endoscopic examination. Histologically, they have villiform architecture with surface epithelium showing pseudostratified, pencillate nuclei and hypereosinophilic cytoplasm. Ectopic crypt formation is a characteristic histology. TSA often contain high grade dysplasia.