Esophagus, Lymphocytic esophagitis [LMP68114]

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Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Cellular Responses to Stress and Toxic Insults: Adaptation, Injury, and Death
Diagnosis: 
Lymphocytic esophagitis
Species: 
Human
Organ System: 
Gastrointestinal Tract
Gender: 
Female
Age: 
32 years
Diagnosis Code: 
ICD-10: K20
Slide Contributor Information
Akbari, A., Kirsch, R.

Keywords

gastroesophageal reflux disease (GERD), eosinophilic esophagitis (EOE)

Clinical History

32 year old female, esophageal biopsy.

Clinical Discussion

Lymphocytic esophagitis is a type of chronic inflammation that can be seen in esophageal biopsies for dysphagia. This esophageal biopsy demonstrates intercellular edema and increased lymphocytic infiltrate (highest count 60/HPF). The lymphocytosis is concentrated in the parapapillary region. There is a lack of eosinophils and neutrophils. Such findings have been described as lymphocytic esophagitis in the literature. There is an association between lymphocytic esophagitis and Crohn’s disease in the pediatric population.