Lymph node, follicular lymphoma [LMP58237]

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Diagnostic Modality: 
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Disease Category: 
Neoplasia
Diagnosis: 
Follicular lymphoma
Species: 
Human
Organ System: 
White Blood Cells, Lymph Nodes, Spleen, and Thymus
Gender: 
Female
Age: 
88 years
Diagnosis Code: 
ICD-10: C82.3 | ICD-O: 9698/3
Slide Contributor Information
Chang, M.

Keywords

B-cell lymphoma, lymphadenopathy

Clinical History

Incidental finding at sentinel lymph node biopsy for breast cancer. Otherwise asymptomatic.

Clinical Discussion

Follicular lymphoma is a non-Hodgkin B-cell lymphoma that is often indolent. The cells resemble lymphoid germinal centre B-cells, and often demonstrate a t(14,18) translocation with overexpression of the anti-apoptotic protein bcl2. WHO grading of follicular lymphoma depends on the number of large centroblasts within the tumour. In this case, centroblasts exceed 15 per high-power fields, without solid sheet-like growth. This meets the criteria for Grade 3A.