Lymph Nodes, Classical Hodgkin lymphoma [LMP90590]

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Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Neoplasia
Diagnosis: 
Classical Hodgkin lymphoma
Species: 
Human
Organ System: 
White Blood Cells, Lymph Nodes, Spleen, and Thymus
Gender: 
Male
Age: 
38 years
Diagnosis Code: 
ICD-10: C81.1 | ICD-O:9663/3
Slide Contributor Information
Hojilla, C., Ghaffar, H.

Keywords

classical Hodgkin lymphoma, Reed-Sternberg cell

Clinical History

Supraclavicular mass biopsy. Bulky mediastinal lympadenopathy on imaging.

Clinical Discussion

Classical Hodgkin lymphoma is one of the most common cancers of young adults and adolescents. Patients present with lymphadenopathy sometimes accompanied by constitutional B symptoms (fever, night sweats and weight loss). It is characterized by the presence of neoplastic lymphocytes of B-cell origin termed Hodgkin Reed-Sternberg cells (large lymphoid cells that contain multinucleated or multilobulated nuclei with prominent viral inclusion-like nucleoli imparting an "owl eye" appearance), and variants (Hodgkin cells). The background consists of abundant mixed inflammatory cells recruited in response to cytokines produced by the tumor, often with a component of eosinophils as is seen in this example. The neoplastic cells are typically positive for CD15, CD30, and PAX-5 (weak), while negative for CD45, CD3 and CD20.