Ovary, Mature cystic teratoma, with well differentiated neuroendocrine tumour ("carcinoid"). [LMP48089]

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Image Details
Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Neoplasia
Diagnosis: 
Mature cystic teratoma, with well differentiated neuroendocrine tumour ("carcinoid").
Species: 
Human
Organ System: 
Female Genital Tract
Gender: 
Female
Age: 
64 years
Slide Contributor Information
Radi, R., Chang, M.

Keywords

ovary, teratoma, carcinoid

Clinical History

64 year-old female with a left ovarian mass measuring 3.0 cm.

Clinical Discussion

Mature cystic teratomas are the most common ovarian germ cell tumour. In rare cases, somatic-type tumours can arise within the mature elements, including well-differentiated neuroendocrine tumours resembling gastrointestinal-type carcinoids. The outcome is generally benign.

In this slide, within a background of mature teratoma, is a 0.5 cm nodule of nests and trabeculae of uniform cells with “salt and pepper” chromatin, and granular eosinophilic cytoplasm is present in the cyst wall. Mitotic count is < 1 per 10 HPF. There is no necrosis. The cells in this nodule are diffusely positive for synaptophysin, chromogranin and CD56.