Skin, Leukocytoclastic vasculitis [LMP33594]

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Image Details
Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Diseases of the Immune System
Diagnosis: 
Leukocytoclastic vasculitis
Species: 
Human
Organ System: 
Skin
Gender: 
Female
Age: 
16 years
Diagnosis Code: 
ICD-10: M32
Slide Contributor Information
Peerani, R., Somers, G.

Keywords

systemic lupus erythematosus , LCV, leukocytoclastic, vasculitis

Clinical History

16 year old with systemic lupus erythematosus (SLE).

Clinical Discussion

Leukocytoclastic vasculitis is a hypersensitivity-related small-vessel vasculitis. Leukocytoclastic refers the accumulation of nuclear debris of neutrophils within the blood vessel walls. Sections show epidermis and dermis. The epidermis is unremarkable. Within the dermis, predominantly affecting the superficial vascular plexus, is an acute vasculitis. There is a perivascular infiltrate of neutrophils associated with leukocytoclasis and extravasated erythrocytes. The vessels show markedly reactive endothelium and there is focal destruction of the vessel wall associated with microscopic fragments of fibrin. The deeper dermis shows a mild but similar perivascular leukocytoclastic infiltrate.