Skin, Superficial fibromatosis, H&E Stain [LMP62381]

LMP62381 Thumbnail
View the Zoomify Image
Image Details
Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Neoplasia
Diagnosis: 
Superficial fibromatosis
Species: 
Human
Organ System: 
Bones, Joints, and Soft-Tissue Tumours
Gender: 
Female
Age: 
47 years
Slide Contributor Information
Yoon, J., Demicco, E.

Keywords

superficial fibromatosis, soft tissue

Clinical History

Skin lesion on the sole of the foot.

Clinical Discussion

Superficial fibromatosis typically occurs in three locations - palm (Dupuytren's contracture), soles (Ledderhose disease) and penis (Peyronie disease). Superficial fibromatosis is a proliferation of myofibroblasts, giving rise to a poorly circumscribed tumour, with vague fascicular architecture. The myofibroblasts from long, "sweeping" fascicles, a pattern that is characteristic in both superficial and deep (desmoid-type) fibromatosis. While nuclear beta-catenin can be seen in superficial fibromatosis, they lack mutations of CTNNB1 (beta-cetenin) or APC genes, suggesting that superficial and deep fibromatoses are genetically distinct entities.See related content for reference.

Related Content

Related External Links: 
Superficial fibromatoses are genetically distinct from deep fibromatoses.