Soft Tissue, Diffuse-type giant cell tumour [LMP63381]

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Image Details
Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Neoplasia
Diagnosis: 
Diffuse-type giant cell tumour
Species: 
Human
Organ System: 
Bones, Joints, and Soft-Tissue Tumours
Gender: 
Male
Age: 
9 years
Diagnosis Code: 
ICD-10: D21 | ICD-O: 9251/0
Slide Contributor Information
Peerani, R., Thorner, P.

Keywords

PVNS, Pigmented villonodular synovitis, tenosynovitis

Clinical History

Right knee mass.

Clinical Discussion

Diffuse-type giant cell tumour (formerly “pigmented villonodular synovitis”) is a joint disease related to inflammation causing a clonal proliferation of synovial-like cells. It typically affects the hip and knee joints but can also occur in the joints of shoulders, hands, elbows, ankle, and foot. The knee is the most common. Sections show a cellular lesion with a vaguely nodular architecture, composed of a heterogeneous population of cells including large epithelioid cells with abundant eosinophilic cytoplasm and vesicular round to oval nuclei, multinucleated osteoclast-like giant cells, hemosiderin-laden macrophages, and foamy macrophages. There is a focal area of necrosis and scarring. An iron stain reveals hemosiderin deposition within the soft tissue and macrophages.