Unknown [LMP23894-U]
Clinical History
This 45 year old man presented to the Emergency Department with a three week history of fevers, night sweats, weight loss, abdominal rash, diarrhea and intermittent rashes. Diagnostic imaging revealed generalized lymphadenopathy, hepatosplenomegaly and ascites. Blood work demonstrated thrombocytopenia of 45. Bone marrow biopsy was arranged, however patient returned with high fevers and a CT scan with possible duodenal perforation. Surgical resection of a perforated ulcer with anastomosis was completed. Surgical pathology demonstrated small bowel with an abnormal infiltration of mast cells with mucosal ulceration and granulation issue.
By immunohistochemistry, the lesional cells show diffuse strong CD68 and CD117 staining. CD2 and CD3 highlight T-cells, CD20 highlights B-cells, CD34 highlights vessels and pankeratin stains mucosa. Ki-67 proliferation index is low and is estimated to be <5%. Postoperatively, the patient was admitted to ICU and slowly deteriorated. Palliative care team was involved and the patient passed away.
By immunohistochemistry, the lesional cells show diffuse strong CD68 and CD117 staining. CD2 and CD3 highlight T-cells, CD20 highlights B-cells, CD34 highlights vessels and pankeratin stains mucosa. Ki-67 proliferation index is low and is estimated to be <5%. Postoperatively, the patient was admitted to ICU and slowly deteriorated. Palliative care team was involved and the patient passed away.
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