Urethra, Urothelial carcinoma, high grade [LMP90433]

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Diagnostic Modality: 
Cytology
Disease Category: 
Neoplasia
Diagnosis: 
Urothelial carcinoma, high grade
Species: 
Human
Organ System: 
Lower Urinary Tract and Male Genital System
Gender: 
Male
Age: 
78 years
Diagnosis Code: 
ICD-10: C67 | ICD-O: 8120/3
Slide Contributor Information
Wong, W., Mete, O.

Keywords

urothelial carcinoma, urine, voided

Clinical History

78 year old male. Voided urine.

Clinical Discussion

Urothelial carcinoma typically has an asymptomatic presentation, but may present with dysuria, urgency or increased frequency of urination. Hematuria is usually microscopic. Cytological features of high grade urothelial carcinoma include high nuclear:cytoplasmic ratio, nuclear hyperchromasia, irregular nuclear contours and coarse nuclear chromatin. An important differential to urothelial carcinoma is polyoma virus-associated “Decoy” cells. However, these cells have a glassy appearance to their nuclei.