Lymph Node, Follicular Lymphoma [LMP28161]

LMP28161 Thumbnail
View the Zoomify Image
Image Details
Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Neoplasia
Diagnosis: 
Follicular Lymphoma, low grade
Species: 
Human
Organ System: 
White Blood Cells, Lymph Nodes, Spleen, and Thymus
Gender: 
Male
Age: 
60 years
Diagnosis Code: 
ICD-10: C82.9 | ICD-O: 9690/3
Slide Contributor Information
Sidiropoulos, K.G., Lu, F.

Keywords

follicular, lymphoma, b-cell, centrocyte, centroblast, BCL2

Clinical History

Lymph node touch preparation.

Clinical Discussion

Follicular lymphoma (FL) is a non-Hodgkin B-cell lymphoma which may be detected on lymphoma protocol including touch preparations and smears from involved lymph nodes. Preparations will demonstrate a predominant population of centrocytic cells which demonstrate scant cytoplasm with a cleaved nucleus, and centroblastic cells which are large cells with pale round nuclei with coarse chromatin and two or more marginal nucleoli. It is recommended to confirm that the cells are neoplastic with flow cytometry; molecular analysis will demonstrate a t(14,18) translocation. Immunohistochemistry will show over-expression of the anti-apoptotic protein BCL2.