Bladder, High grade papillary urothelial carcinoma [LMP17098]

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Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Neoplasia
Diagnosis: 
High grade papillary urothelial carcinoma
Species: 
Human
Organ System: 
Lower Urinary Tract and Male Genital System
Gender: 
Male
Age: 
75 years
Diagnosis Code: 
ICD-10: C67 | ICD-O: 8130/2
Slide Contributor Information
Hodgson, A., Sugar, L.

Keywords

bladder, papillary, high grade, invasive

Clinical History

Cystoprostatectomy, known bladder lesion.

Clinical Discussion

High grade papillary urothelial carcinoma is a lesion in the spectrum of papillary urothelial neoplasia.The high grade version shows a disorderly appearance of the urothelium with easily recognizable architectural and cytological abnormalities.

Some of the specific microscopic findings one would see include cytological pleomorphism ranging from moderate to marked, clumped chromatin, prominent nucleoli, mitotic figures at all levels of urothelium, variation of urothelial thickness, and papillae that are frequently fused.

This case shows invasion into the lamina propria.