Brain, Amyloid-beta related angiitis [LMP36980]

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Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Diseases of the Immune System
Diagnosis: 
Amyloid-beta related angiitis
Species: 
Human
Organ System: 
Central Nervous System
Gender: 
Female
Age: 
67 years
Diagnosis Code: 
ICD-10: I68.0
Slide Contributor Information
Gao, A., Munoz, D.

Keywords

Cerebral amyloid angiopathy, cerebral congophilic angiopathy, CNS vasculitis, cerebral amyloid angiopathy-related inflammation

Clinical History

67-year-old woman with chronic headaches. Neuroimaging shows a large right-sided lesion expanding the cortex and white matter accompanied by significant mass effect. Punctate foci of susceptibility artifact (microhemorrhages) were also noted.

Clinical Discussion

Amyloid-beta related angiitis is a vascular condition related to both cerebral amyloid angiopathy (CAA) and primary angiitis of the CNS (PACNS). In CAA, there is deposition of amyloid-beta into the walls of superficial vessels that classically cause lobar and microhemorrhages. PACNS is a primary vasculitis of the CNS. Amyloid-beta related angiitis combines features of both conditions with deposition of amyloid-beta accompanied by an inflammatory vasculitic component. Its appearance on neuroimaging can be misinterpreted as a mass lesion or tumour.

Related Content

Related External Links: 
Nouh et al. Amyloid-Beta Related Angiitis of the Central Nervous System: Case Report and Topic Review. Frontiers in Neurology...