Breast, Adenoid cystic carcinoma [LMP23525]

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Diagnostic Modality: 
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Disease Category: 
Neoplasia
Diagnosis: 
Adenoid cystic carcinoma
Species: 
Human
Organ System: 
Breast
Gender: 
Female
Age: 
49 years
Diagnosis Code: 
ICD-10: C50 | ICD-O: 8200/3
Slide Contributor Information
Boles, D., Mete, O.

Keywords

adenoid cystic carcinoma, triple negative breast cancer

Clinical History

49 year old female with breast mass.

Clinical Discussion

Mammary adenoid cystic carcinoma is very rare. Although triple negative, it is one of the more indolent breast cancers if completely excised. This tumour is morphologically identical to its counterpart in the salivary gland.

Adenoid cystic carcinoma is characterized by a dual-cell population: a ductal-luminal, and myoepithelial-basaloid. The overall architecture can be cribriform, trabecular, or solid. It harbours recurrent chromosomal translocation t(6:9) involving MYB and NFIB genes.

The differential diagnosis includes collagenous spherulosis, cribriform DCIS, and cribriform carcinoma.