Breast, Amyloidosis [LMP61379]

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Diagnostic Modality: 
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Disease Category: 
Neoplasia
Diagnosis: 
Amyloidosis
Species: 
Human
Organ System: 
Breast
Gender: 
Female
Age: 
61 years
Diagnosis Code: 
ICD-10: E85
Slide Contributor Information
Wong, W., Lu, F.

Keywords

amyloid, incidental plasmacytoma, breast, amyloidosis

Clinical History

61 year old female with right breast calcification.

Clinical Discussion

Amyloid deposition is an extracellular deposit of proteins as fibrillar beta-pleated sheets. These deposits can be prone to calcify and present as breast calcifications in a patient undergoing breast cancer screening. In this case, there is abundant dense, amorphous pink material scattered within the breast tissue and associated with calcifications. There is no associated ductal component. There are scattered areas with giant cell reaction and foci with abundant plasma cells.

An important differential to amyloid in the breast is dense collagen that may be seen in hyalinized fibroadenoma or sclerosing lesions. These differentials could be ruled out by Congo red stain. A significant amount of cases of amyloidosis in breast are associated with hematological disorders (Said, SM, et al.). This patient also has an incidental plasma cell neoplasm.

See related content for references:

1) Said SM, et al. Mod Pathol. 2013 Feb;26(2):232-8.

Related Content

Related External Links: 
Said, SM, et al. Amyloidosis of the breast: predominantly AL type and over half have concurrent breast hematologic disorders...