Breast, Angiosarcoma [LMP59638]

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Diagnostic Modality: 
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Disease Category: 
Neoplasia
Diagnosis: 
Angiosarcoma
Species: 
Human
Organ System: 
Breast
Gender: 
Female
Age: 
71 years
Diagnosis Code: 
ICD-10: C50 | ICD-O: 9120/3
Slide Contributor Information
Forse, C., Latta, E.

Keywords

Radiation-induced

Clinical History

Left breast mastectomy, with remote history of breast carcinoma.

Clinical Discussion

Angiosarcoma is a malignant vascular neoplasm of the breast that may arise as an idiopathic (primary) lesion or may arise secondary to local radiation to the breast for invasive breast carcinoma. Radiation-induced angiosarcoma usually arises 5-6 years after the completion of radiation treatment. Radiation induced angiosarcomas often have MYC amplification (55-65% of cases) which is not typically seen in non-radiation induced angiosarcoma or other atypical vascular lesions. Post-surgical arm edema after breast and axillary surgery for cancer increases the risk for angiosarcoma of the skin (called Stewart-Treves syndrome).

Histologically, angiosarcoma is characterized by irregular anastomosing vascular channels with irregular, infiltrative margins. Endothelial cells are pleomorphic and may increase to form papillary tufts within the vascular spaces.