Breast, Malignant phyllodes tumour, H&E stain [LMP92842]

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Image Details
Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Neoplasia
Diagnosis: 
Malignant phyllodes tumour
Species: 
Human
Organ System: 
Breast
Gender: 
Female
Age: 
62 years
Slide Contributor Information
Chang, M.

Keywords

phyllodes tumor

Clinical History

Right breast, 6 cm circumscribed mass.

Clinical Discussion

Malignant phyllodes tumours are fibroepithelial neoplasms with malignant stromal growth. Criteria for malignancy include stromal overgrowth, stromal hypercellularity, stromal cell atypia, mitotic activity, and invasive tumour borders. In this case, even though stromal overgrowth and heterologous elements are not seen, there is marked pleomorphic atypia and marked cellularity, along with increased mitotic activity (at least 9 per 10 high power fields).