Cervix, stratified‐type adenocarcinoma in situ [LMP84629]

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Image Details
Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Neoplasia
Diagnosis: 
Adenocarcinoma in situ, stratified type
Species: 
Human
Organ System: 
Female Genital Tract
Gender: 
Female
Age: 
42 Years
Diagnosis Code: 
ICD‐10: D06.0 | ICD‐O: 8140/2
Slide Contributor Information
Chang, M.

Keywords

Stratified, mucin, intraepithelial lesion, SMILE

Clinical History

Abnormal Pap smear; biopsy taken at colposcopy.

Clinical Discussion

Adenocarcinoma in situ (AIS) is a lesion of the cervical glands that carries significant risk of invasive adenocarcinoma.This case is a variant of AIS, the stratified‐type (also referred to as a stratified mucin‐production intraepithelial lesion or SMILE) consists of stratified epithelium with cells containing mucin. It can be difficult to distinguish from reactive squamous metaplasia, and the diagnosis is made based on the degree of cytologic atypia throughout the neoplastic cells.