Colon, Sessile serrated adenoma [LMP67008]

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Image Details
Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Neoplasia
Diagnosis: 
Sessile serrated adenoma
Species: 
Human
Organ System: 
Gastrointestinal Tract
Gender: 
Female
Age: 
29 years
Diagnosis Code: 
ICD-10: D12.6 | ICD-O: 8213/0
Slide Contributor Information
Akbari, A., Kirsch, R.

Keywords

sessile serrated adenoma , SSA

Clinical History

Colon biopsy.

Clinical Discussion

Sessile serrated adenomas have an incidence of 1-10% of all colorectal polyps. They are usually right sided, and the median age of affected patients is 61-62 years. Molecular characteristics include CpG island methylation phenotype and BRAF oncogene activating mutations.

Microscopically, they are characterized by serration (resulting from in-folding of crypt epithelium), dilatation and exaggerated serration extending down to crypt base, branching or lateral growth of crypt along muscularis mucosae, and L-boot shaped crypt bases.