Endocervix, adenocarcinoma [LMP80095]

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Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Neoplasia
Diagnosis: 
Inasive adenocarcinoma, Grade-2 adenocarcinoma in situ (AIS), usual (endocervical) and intestinal types
Species: 
Human
Organ System: 
Female Genital Tract
Gender: 
Female
Age: 
40 years
Diagnosis Code: 
ICD-10: 53.0 | ICD-O: 8140/3
Slide Contributor Information
Azordegan, N., Dube, V., Cesari, M.

Keywords

AIS, adenocarcinoma, usual type, intestinal type, cervical carcinoma, cervix

Clinical History

Loop Electrosurgical Excision Procedure (LEEP) on a 40 year-old female with clinical history of Adenocarcinoma in situ/High-grade squamous intraepithelial lesion (AIS/HSIL).

Clinical Discussion

Usual type endocervical adenocarcinoma is the most common form (90%) of cervical adenocarcinoma and often presents as abnormal uterine bleeding or a mass. These tumors are almost always associated with high risk HPV and are usually well to moderately differentiated with mucin poor glands and characteristic pseudostratified architecture with enlarged elongated and hyperchromatic nuclei and apical (floating) mitotic figures.

Mucinous carcinoma, intestinal type shows intestinal differentiation and recapitulates intestinal adenocarcinomas. High risk HPV has been detected in this variant as well.