Kidney, Mucinous tubular and spindle cell carcinoma [LMP73365]

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Image Details
Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Neoplasia
Diagnosis: 
Mucinous tubular and spindle cell carcinoma
Species: 
Human
Organ System: 
Kidney
Gender: 
Male
Age: 
54 years
Diagnosis Code: 
ICD-10: C64 | ICD-O: 8010/3
Slide Contributor Information
Shao, T., Mete, O.

Keywords

genitourinary, kidney, mucinous tubular, spindle cell

Clinical History

Left partial nephrectomy for a tumour measuring 4.8 cm in a 54 year old male.

Clinical Discussion

Mucinous tubular and spindle cell carcinoma is a relatively rare neoplasm, accounting for less than 1% of all renal neoplasms. It is characterized by a low-grade biphasic carcinoma, and it is usually associated with a favorable prognosis. Grossly, it is often a well-circumscribed mass with gray-white to tan or yellow cut surface, usually centered in the medulla of the kidney.

The section shows a well-circumscribed mass with tightly packed elongated, branching tubules lined by low columnar or cuboidal, with uniform, low-grade, round nuclei. There are scattered areas of foamy macrophages among the tubules. The bland spindle cells appear to be intimately admixed with the tubular component. The juxtaposition of these 2 features is typical in mucinous tubular and spindle cell carcinoma.