Kidney, Papillary renal cell carcinoma [LMP95224]

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Image Details
Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Neoplasia
Diagnosis: 
Papillary renal cell carcinoma
Species: 
Human
Organ System: 
Kidney
Gender: 
Male
Age: 
51 years
Diagnosis Code: 
ICD-10: C64 | ICD-O: 8260/3
Slide Contributor Information
Shao, T., Latta, E.

Keywords

papillary, renal, carcinoma

Clinical History

Right renal mass.

Clinical Discussion

Papillary renal cell carcinoma (PRCC) is the second most common subtype of renal cell carcinoma (RCC), often showing predominant or exclusive papillary architecture, with a well-formed tumour capsule. Most of the sporadic PRCCs are characterized by trisomy of chromosomes 7 and 17, as well as loss of chromosome Y.

The section shows a well-circumscribed lesion with a papillary architecture in the form of discrete papillary fronds lined by neoplastic cells, with central fibrovascular cores. The papillae are covered by neoplastic cells with clear to amphophilic cytoplasm in a single cell layer. The cores of the papillae show variable amounts of foamy macrophages.