Lymph Nodes, Burkitt lymphoma [LMP37486]

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Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Neoplasia
Diagnosis: 
Burkitt lymphoma
Species: 
Human
Organ System: 
White Blood Cells, Lymph Nodes, Spleen, and Thymus
Gender: 
Male
Age: 
22
Diagnosis Code: 
ICD-10: C83.7 | ICD-O: 9687/3
Slide Contributor Information
Hojilla, C., Ghaffar, H.

Keywords

Burkitt lymphoma, C-MYC, non-Hodgkin lymphoma, EBV, Epstein-Barr virus

Clinical History

22 year-old male. Right axilla lymph node biopsy. Rapidly enlarging axillary lymphadenopathy with tenderness. No constitutional or B symptoms.

Clinical Discussion

Burkitt lymphoma is a clinically aggressive form of non-Hodgkin B-cell lymphoma with an extremely rapid rate of growth, reflected by the presence of tingible body macrophages containing phagocytosed nuclear debris imparting a "starry sky pattern." Subtypes of Burkitt lymphoma include African endemic, sporadic and immunodeficiency-associated. The African endemic form usually occurs in children, generally involves the jaw, facial bones and orbit, and shows evidence of latent infection with Epstein Barr virus. Genetic rearrangements involving C-MYC, most commonly t(8;14), are typical. The tumor consists of medium-sized monomorphous lymphocytes with brisk mitotic activity and well-defined (squared off) cell borders. The immunophenotype of Burkitt lymphoma is analogous to that of germinal centers from which it originates: CD20+/CD10+/BCL6+/BCL2- with a Ki-67 proliferation rate of 100%.