Nasal Cavity, Langerhan cell histiocytosis, H&E stain [LMP97924]
Keywords
Langerhans cell histiocytosis, LCH, nasal cavity
Clinical History
2 year old male, presented with nasal polyps and multiple bone lesions.
Clinical Discussion
Langerhan cell histiocytosis (LCH) is a rare histiocytic disorder, believed to represent a clonal proliferation of Langerhan cells. It has been historically referred to as histiocytosis X, Hand-Schuller-Christian disease and Letterer-Siwe disease. The multisystem/multifocal form predominantly affects children with a male predominance. It commonly presents with lytic bone lesion(s). However, it can also involve skin, liver, spleen, lymph node, and bone marrow. Microscopically, the neoplastic cells have a “coffee-bean” appearance with elongated nuclei and nuclear grooves, along with abundant eosinophilic cytoplasm. The Langerhan cells are embedded in a milieu composed of variable number of eosinophils, neutrophils and small lymphocytes. These cells express CD1a, langerin (CD207), and S100 protein. In this case, within the fragments of the nasal polyp resection, there are numerous Langerhan cells and eosinophils within a loose, edematous inflammatory mucosa.
This slide shows H&E stain. See related content for CD1a and S100 stains.
This slide shows H&E stain. See related content for CD1a and S100 stains.
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