Ovary, Leydig cell tumour [LMP31571]

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Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Neoplasia
Diagnosis: 
Leydig cell tumour
Species: 
Human
Organ System: 
Female Genital Tract
Gender: 
Female
Age: 
49 years
Diagnosis Code: 
ICD-10: D27 | ICD-O: 8650/0
Slide Contributor Information
Yoon, J., Chang, M.

Keywords

leydig cell tumour, hilus cell tumour

Clinical History

49 year-old female patient with a unilateral ovarian tumour.

Clinical Discussion

Sections show a well demarcated lesion composed of sheets of round-polygonal cells with abundant eosinophilic cytoplasm. Occasional bizarre atypia is noted. An important histological finding is the presence of Reinke crystals: rectangular, eosinophilic intracytoplasmic crystals, which are characteristic and necessary for distinguishing from other steroid cell tumours.

The lesion showed immunoreactivity for inhibin, calretinin, and MART-1 (not shown), which are supportive of this diagnosis.

Signs and symptoms related to excess androgen are commonly encountered in these patients. Prognosis is excellent, and unilateral salpingo-oophorectomy is generally sufficient for management.

Compare this case with an example of Sertoli-Leydig cell tumour, LMP12501 (see Related Content)

Related Content

Related External Links: 
LMP12501 - Ovary, Sertoli-Leydig cell tumour