Parotid gland, Adenoid cystic carcinoma [LMP84410]

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Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Neoplasia
Diagnosis: 
Adenoid cystic carcinoma
Species: 
Human
Organ System: 
Head and Neck
Gender: 
Male
Age: 
61 years
Diagnosis Code: 
ICD-10: C07 | ICD-O: 8200/3
Slide Contributor Information
Lou, S., Mete, O.

Clinical History

61 year old male with facial pain and right parotid mass.

Clinical Discussion

Adenoid cystic carcinoma (ACC) accounts for about 10% of salivary gland carcinomas. It most frequently occurs in the major salivary glands but has been reported in the oral cavity, sinonasal tract and rarely, other sites. It typically presents as a slow-growing mass with numbness, paraesthesia or pain due to its propensity for neural invasion. It is generally indolent but long-term prognosis is poor as it is associated with a protracted course of multiple recurrences and metastases.

ACC is a malignancy composed of epithelial and myoepithelial neoplastic cells. Most commonly, it exhibits a cribiform growth pattern (as in this case) with sharp punch-out spaces filled with basophilic matrix of tumor cell nests. However, it can also exhibit tubular and solid growth patterns. Perineural invasion is usually conspicuous. MYB fusion, including MYB-NFIB translocation is found in greater than 80% of ACCs.

Related Content

Related External Links: 
WHO classification of tumours. Pathology and genetics of head and neck tumours.