Peripheral Blood, Acute myeloid leukemia [LMP25507]

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Image Details
Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Neoplasia
Diagnosis: 
Acute myeloid leukemia
Species: 
Human
Organ System: 
White Blood Cells, Lymph Nodes, Spleen, and Thymus
Gender: 
Female
Age: 
40 years
Diagnosis Code: 
ICD-10: C92.0 | ICD-O: 9861/3
Slide Contributor Information
Hosseini, N., Mete, O.

Keywords

acute leukemia, acute myeloid leukemia

Clinical History

40-year old female evaluated in ER for chest pain.

Clinical Discussion

Acute myeloid leukemia (AML) is the most common leukemia in adults. It is a neoplastic proliferation of myeloid precursors in which myeloid blasts replace the marrow, resulting in bone marrow failure, anemia, thrombocytopenia and neutropenia.

This section demonstrates a peripheral blood smear composed mainly of blasts and a decrease in mature granulocytes and monocytes.

To diagnose AML, blasts or blast equivalents should comprise ≥ 20% of nucleated peripheral blood and/or bone marrow cells, and there should be no history of chemotherapy, radiotherapy or AML-defining cytogenetic abnormalities.