Placenta, Fetal thrombotic vasculopathy [LMP75428]

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Diagnostic Modality: 
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Disease Category: 
Hemodynamic Disorders, Thromboembolic Disease and Shock
Diagnosis: 
Fetal thrombotic vasculopathy
Species: 
Human
Organ System: 
Female Genital Tract
Gender: 
Female
Diagnosis Code: 
ICD-10: O36.8
Slide Contributor Information
Duan, K., Taylor, G.

Keywords

placenta, intrauterine growth restriction, neurologic, vasculopathy

Clinical History

The placenta is that of a newborn born at 35 weeks of gestational age and admitted to NICU. The mother was 49 years old and G1P0. This was an IVF pregnancy. The baby was delivered by c-section due to abnormal fetal surveillance and oligohydramnios.

Clinical Discussion

Fetal thrombotic vasculopathy (FTV) encompasses a wide variety of fetal perfusion pathologies, including those that are thromboembolic (i.e. fetal diffuse intravascular coagulopathy, true umbilical knots, maternal or fetal thrombophilia), related to fetal heart failure and/or fetal vascular wall damage. Clinically, FTV is associated with adverse pregnancy outcomes including IUGR, intrauterine fetal demise and neonatal neurologic compromise. Histologically, this condition is characterized by the presence of avascular villi with no fetal perfusion. The intervillous spaces (maternal lakes) are generally patent.

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Related Content

Related External Links: 
Roberts DJ. Placental pathology, a survival guide. Arch Pathol Lab Med. 2008;132(4):641-651.