Placenta, partial hydatidiform mole, p57 stain [LMP44979]
Keywords
Partial hydatidiform mole, gestational trophoblastic disease
Clinical History
32 years old female - uterine curettings for missed abortion.
Clinical Discussion
Partial hydatidiform mole is a product of conception with abnormal chorionic villi due to a chromosomal abnormality (triploidy). This can arise, for example, with fertilization by two sperm. Partial mole is characterized by two populations of villi; sclerotic and enlarged. The latter shows scalloped borders and trophoblastic inclusions with lacy proliferation of syncytiotrophoblasts. Unlike a complete mole, which lacks maternal DNA, partial moles show retention of the maternally expressed p57 protein in stromal villous cells and cytotrophoblast.
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