Rectum, Recto-sigmoid adenocarcinoma with large-vessel invasion, H&E stain [LMP50222]
Keywords
sigmoid, colorectal cancer, vascular invasion, adenocarcinoma
Clinical History
60-year old male with painless jaundice.
Clinical Discussion
Colorectal adenocarcinoma is a common malignancy requiring pathologic evaluation for prognosis and staging. Section from a low anterior resection shows large vessel invasion by adenocarcinoma, and the vessel is highlighted by EVG stain (see Related Content). While significant inter-observer variability in their detection has been reported, large-vessel invasion is believed to carry an increased risk. While not part of the CAP protocol, large-vessel invasion warrants a separate comment. EVG stain nicely highlights the elastic tissue in this case, but trichrome stain can also be employed.
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