Skin, Discoid lupus erythematosus, PAS stain [LMP20837]
Keywords
discoid lupus erythematosus
Clinical History
53-year old female patient with scaly skin patches on face and ears.
Clinical Discussion
Lupus is an extremely heterogeneous disease that can affect multiple organs. Chronic cutaneous lupus erythematosus can be further sub-divided into discoid lupus erythematosus (DLE), tumid lupus, and lupus panniculitis. DLE may occur in the absence of systemic disease, or may occur in association with systemic lupus erythematosus (SLE). Interestingly, in this patient, a separate, simultaneous biopsy demonstrated eosinophilic cellulitis (Wells Syndrome). Although these represent distinct diagnoses, a common pathophysiology cannot be excluded in this case (see related content).
Sections show parakeratosis, and heavy perivascular lympho-histiocytic infiltrates, with plasma cells. The basement is thickened, and this can be highlighted by PAS. Hales colloidal iron stain shows mucin accumulation.
This slide shows PAS stain, see related content for H&E and colloidal iron stains.
Sections show parakeratosis, and heavy perivascular lympho-histiocytic infiltrates, with plasma cells. The basement is thickened, and this can be highlighted by PAS. Hales colloidal iron stain shows mucin accumulation.
This slide shows PAS stain, see related content for H&E and colloidal iron stains.
Related Content
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