Skin, Kaposi sarcoma [LMP13822]

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Diagnostic Modality: 
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Disease Category: 
Neoplasia
Diagnosis: 
Kaposi sarcoma
Species: 
Human
Organ System: 
Skin
Gender: 
Female
Age: 
60 years
Diagnosis Code: 
ICD-10: C46.0 | ICD-O: 9140/3
Slide Contributor Information
Boles, D., Sade, S.

Clinical History

60 year-old female with multiple nodules on right leg.

Clinical Discussion

Kaposi sarcoma is a malignant vascular neoplasm associated with human herpesvirus-8 (HHV-8). Sections show a lesion characterized by prominent spindle cell proliferation and slit-like spaces containing red blood cells. A lymphocytic infiltrate is typically present. By immunohistochemistry, CD31, D2-40, ERG and HHV-8 are positive.