Skin, Schwannoma [LMP13836]

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Image Details
Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Neoplasia
Diagnosis: 
Schwannoma
Species: 
Human
Organ System: 
Skin
Gender: 
Female
Age: 
29 years
Diagnosis Code: 
ICD-10: D23 | ICD-O: 9560/0
Slide Contributor Information
Yu, Y., Sade, S.

Keywords

neural sheath tumour

Clinical History

Right pectoralis minor tissue excision from a 29 year-old woman.

Clinical Discussion

Schwannoma is a benign neural sheath tumor that exhibits Schwann cell differentiation. It is a slow growing tumour and recurrence is rare. Common sites include posterior spinal roots, head and neck regions, and flexors of extremities.

Microscopically, wavy spindle-shaped Schwann cells can be seen. Areas that appear dense and eosinophilic are called Antoni A regions, while the Antoni B regions correspond to the looser, hypocellular areas with myxoid component. Verocay bodies, areas that contain distinct palisading nuclei adjacent to nuclear-free zones, can also be observed in Antoni A regions.