Skin, Seborrheic keratosis [LMP24026]

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Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Neoplasia
Diagnosis: 
Seborrheic keratosis
Species: 
Human
Organ System: 
Skin
Gender: 
Female
Age: 
50 years
Diagnosis Code: 
ICD-10: L82
Slide Contributor Information
Yoon, J., Al-Habeeb, A.

Keywords

seborrheic keratosis

Clinical History

50-year old female with an arm lesion.

Clinical Discussion

Seborrheic keratosis (SK) is a common diagnosis, and it exists in many forms. This example is a commonly encountered form of SK, with an exophytic pattern, showing keratin-filled “horn” cysts.

While it is a benign entity, activating mutations in FGFR3 have been found in many sporadic lesions and are thought to drive proliferation (Hafner et al. Modern Pathology (2007) 20, 895–903). Malignant tumours developing within SK is seen in extremely rare cases, and most cases reported were cases of basal cell carcinoma (BCC). The exact relationship between SK and BCC is unclear.

See related contents for references:

1) Hafner et al. Modern Pathology (2007) 20, 895–903

Related Content

Related External Links: 
Hafner et al. FGFR3 mutations in seborrheic keratoses are already present in flat lesions and associated with age and localiz...