Skin, Trichilemmoma [LMP16909]

LMP16909 Thumbnail
View the Zoomify Image
Image Details
Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Neoplasia
Diagnosis: 
Trichilemmoma
Species: 
Human
Organ System: 
Skin
Gender: 
Male
Age: 
68 years
Diagnosis Code: 
ICD-10: D22 | ICD-O: 8102/0
Slide Contributor Information
Boles, D., Sade, S.

Clinical History

68 year-old male with skin-coloured papule on his upper lip.

Clinical Discussion

Trichilemmoma is a benign tumour of the hair follicle, arising in the outer root sheath. Sections show epidermal based proliferation (related to the follicular root sheath) of uniform small cells with peripheral palisading and adjacent hyalinized basement membrane. Clear cell change can be seen due to intracytoplasmic glycogen. Multiple lesions are associated with Cowden disease, with mutation in PTEN gene.