Soft Tissue, Extraskeletal myxoid chondrosarcoma [LMP75673]

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Image Details
Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Neoplasia
Diagnosis: 
Extraskeletal myxoid chondrosarcoma
Species: 
Human
Organ System: 
Bones, Joints, and Soft-Tissue Tumours
Gender: 
Female
Age: 
62 years
Diagnosis Code: 
ICD-10: C47 | ICD-O: 9231/3
Slide Contributor Information
Howarth, D., Nanji, S., Chang, M.

Keywords

sarcoma, chondroid, cartilage

Clinical History

Biopsy of a soft tissue lesion adjacent to the knee, in a middle-aged woman.

Clinical Discussion

Extraskeletal myxoid chondrosarcoma is a malignant tumour that resembles cartilage, but is of uncertain differentiation. This slide is from a core biopsy. Nevertheless, it illustrates well the main features of multinodularity, abundant myxoid matrix, and small chondroblast-like cells arranged in loose cords. The chondroid matrix can be further highlighted using a toluidine blue stain. The tumour cells are S100 and vimentin positive, keratin negative. Around half of cases demonstrate rearragment of the EWS gene.