Soft tissue, neurofibroma [LMP16706]

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Image Details
Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Neoplasia
Diagnosis: 
Neurofribroma
Species: 
Human
Organ System: 
Bones, Joints, and Soft-Tissue Tumours
Gender: 
Female
Age: 
53 years
Diagnosis Code: 
ICD-10: Q85.0 | ICD-O: 9540/1
Slide Contributor Information
Mrkonjic, M., Chang, M.

Keywords

Neurofibromatosis, peripheral nerve sheath, NF, NF1, von Recklinghausen, skin

Clinical History

The patient has a history of Neurofibromatosis Type 1. She developed a retroperitoneal malignant peripheral nerve sheath tumour, which was resected and treated with adjuvant radiation. This specimen represents incidental skin nodules found at the time of surgical evaluation.

Clinical Discussion

Neurofibroma is a tumour of the cells of the nerve sheath that can occur both associated with neurofibromatosis (especially NF1) or sporadically. This example is from a patient with known NF1. The findings are of a well demarcated non-encapsulated cutaneous tumour composed of interlacing fascicles of bland spindled-to-ovoid cells with wavy dark nuclei. There is no mitotic activity or necrosis. The underlying stroma consists of coarse collagen bundles and the overlying epidermis is unremarkable.