Soft Tissue, Subcutaneous panniculitis-like T-cell lymphoma, TCR beta stain [LMP33366]
Keywords
Subcutaneous panniculitis-like T-cell lymphoma, Panniculitic T-cell lymphoma, immunoblastic
Clinical History
Left upper arm soft-tissue biopsy.
Clinical Discussion
This is a rare form of primary cutaneous T-cell lymphoma, predominantly affecting the subcutaneous fatty tissue. It is a cytotoxic T-cell lymphoma that preferentially involves subcutaneous tissue and expresses TCR-αβ. The dense lymphoid infiltration primarily involves the subcutaneous adipose tissue. Close look at the malignant cells reveal obvious atypia, with pleomorphism and numerous mitotic figures.
Demonstration of TCR-αβ is important, considering the differential diagnosis of primary cutaneous γδ T-cell Lymphoma. Mature T-cell phenotype is observed, with aberrant loss of CD5, CD7, and CD2 (in decreasing order). The majority of cases will show CD8 positivity.
This lymphoma is a clinically indolent entity, but progression can be seen.
This slide shows TCR beta stain. See Related Content for H&E, CD3, CD7, and CD8 stains.
Demonstration of TCR-αβ is important, considering the differential diagnosis of primary cutaneous γδ T-cell Lymphoma. Mature T-cell phenotype is observed, with aberrant loss of CD5, CD7, and CD2 (in decreasing order). The majority of cases will show CD8 positivity.
This lymphoma is a clinically indolent entity, but progression can be seen.
This slide shows TCR beta stain. See Related Content for H&E, CD3, CD7, and CD8 stains.
Related Content
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