Spleen, Littoral cell angioma [LMP24098]

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Image Details
Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Neoplasia
Diagnosis: 
Littoral cell angioma
Species: 
Human
Organ System: 
White Blood Cells, Lymph Nodes, Spleen, and Thymus
Gender: 
Male
Age: 
73 years
Diagnosis Code: 
ICD-10: D36.7
Slide Contributor Information
Starova, B., Lu, F.

Keywords

spleen, angioma, littoral

Clinical History

Splenic mass.

Clinical Discussion

Littoral cell angioma is a relatively uncommon, benign, primary vascular lesion of the spleen. Grossly, it is characterized by multiple spongy, cystic nodules. Microscopically, the cystic spaces are composed of anastomosing vascular spaces of varying diameter, lined by cuboidal to tall cells with occasional papillary structures. The lumina often contain abundant exfoliated cells. There is typically no cytological atypia, necrosis, or mitoses. By immunohistochemistry, they tend to show a histiocytic and endothelial immunophenotype, being positive for both CD31/Factor VIII and CD68. CD34 is typically negative.