Testis, Mixed germ cell tumour [LMP54949]

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Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Neoplasia
Diagnosis: 
Mixed germ cell tumour
Species: 
Human
Organ System: 
Lower Urinary Tract and Male Genital System
Gender: 
Male
Age: 
32 years
Diagnosis Code: 
ICD-10: C62.1 | ICD-O: 9085/3
Slide Contributor Information
Hodgson, A., Sugar, L.

Keywords

testis, germ cell tumour, embryonal, yolk sac, teratoma

Clinical History

Self-detected 4.5 cm testicular mass.

Clinical Discussion

The overwhelming majority of testicular tumours are derived from germ cells. There are different histologic subtypes of germ cell tumours which are generally divided in seminomatous and non-seminomatous tumours. Germ cell tumours may be composed of a single histologic subtype, but it is more common for it to be composed of two or more subtypes (as in this case).

The tumour was composed of 97% embryonal carcinoma, 2% yolk sac tumour, and 1% teratoma. There was lymphovascular invasion as well as involvement of the rete testis. There is notable hemorrhage and necrosis. The seminiferous tubules do not appear entirely normal, with features suggestive of intratubular germ cell neoplasia.