Uterus, Adenosarcoma [LMP40737]

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Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Neoplasia
Diagnosis: 
Adenosarcoma
Species: 
Human
Organ System: 
Female Genital Tract
Gender: 
Female
Age: 
65 years
Diagnosis Code: 
ICD-10: C54 | ICD-O: 8933/3
Slide Contributor Information
Duan, K., Lu, F.

Keywords

uterus, cancer, Müllerian, uterine corpus

Clinical History

Uterine mass.

Clinical Discussion

Uterine adenosarcoma is a relatively rare tumor of the gynecological tract that comprises both benign epithelial elements and malignant stromal components. Morphologically, this lesion is characterized by a broad "leaflike" architectural pattern, analogous to that of phyllodes tumors of the breast. For instance, periglandular cuffing of the stromal cells around the compressed or cystically dilated glands is frequently observed. The epithelial component usually shows endometrioid type morphology with possible squamous or mucinous metaplasia, whereas the stromal component is typically a low-grade spindle cell sarcoma. Important prognostic factors to assess in these tumors include the presence of myometrial invasion and sarcomatous overgrowth.

See Related Content for references:

1) Pinto A, Howitt B. Arch Pathol Lab Med. 2016;140(3):286-290.

Related Content

Related External Links: 
Pinto A, Howitt B. Uterine Adenosarcoma. Arch Pathol Lab Med. 2016;140(3):286-290.