Uterus, Lipoleiomyoma [LMP27645]

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Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Neoplasia
Diagnosis: 
Lipoleiomyoma
Species: 
Human
Organ System: 
Female Genital Tract
Gender: 
Female
Age: 
36 years
Diagnosis Code: 
ICD-10: D25 | ICD-O: 8890/0
Slide Contributor Information
Carrigan, S., Kudsia, S.

Keywords

lipoleiomyoma, leiomyoma, benign, smooth muscle, uterus

Clinical History

Hysterectomy and bilateral salpingo-oophorectomy (BSO).

Clinical Discussion

Lipoleiomyoma is a fat containing variant of leiomyoma, a benign smooth muscle neoplasm of the uterus.

Grossly it has soft yellow areas and dense white areas. Microscopically this corresponds to the areas of mature fat and benign smooth muscle proliferation, respectively. The amount of fat is variable; pure lipomas had been described but rare.

HMB45 immunohistochemical staining is negative, which is helpful when PEComa (perivascular epithelioid cell) is on the differential diagnosis.

Lipoleiomyomas are rare. They are included in a group of “leiomyomas with heterologous elements”. Other heterologous elements described in association with leiomyomas are brown fat, skeletal muscle, cartilage and bone.