Uterus, high‐grade endometrial stromal sarcoma [LMP20557]

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Image Details

Diagnostic Modality:

Whole Slide Image

Disease Category:

Neoplasia

Diagnosis:

High‐grade endometrial stromal sarcoma

Species:

Human

Organ System:

Female Genital Tract

Gender:

Female

Age:

56 Years

Diagnosis Code:

ICD‐10: C54.1 | ICD‐O: 8930/3

Slide Contributor Information

Parra-Herran, C., Chang, M.

This high‐grade malignant tumour of endometrial stromal derivation is rare. In many cases, it is associated with a distinct chromosomal translocation: t(10;17), resulting in the YWHAE‐FAM22 fusion gene. It is characterized by a mixture of high‐grade round cells and low‐grade spindle cell components. There is a delicate capillary network. Mitoses are numerous. This biopsy represents only a small sampling of the larger mass (see link to a slide from the hysterectomy in the Related Content section).

The tumour is immunohistochemically positive for CD10 and cyclin‐D1, negative for caldesmon (see attached supplementary images in the Related Content section).