Stomach, juvenile polyp [LMP51974]

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Image Details
Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Neoplasia
Diagnosis: 
Juvenile Polyposis Syndrome
Species: 
Human
Organ System: 
Gastrointestinal Tract
Gender: 
Female
Age: 
25 years
Diagnosis Code: 
ICD-10: K31.7
Slide Contributor Information
Forse, C., Chang, M.

Keywords

juvenile, juvenile polyposis syndrome, stomach, hamartoma, hamartomatous

Clinical History

Upon colonoscopy/endoscopy, two polyps were noted in the rectum and 6-10 polyps were noted in the antrum of the stomach. The attached image represents the largest gastric polyp that was removed.

Clinical Discussion

A juvenile polyp is described as a polyp with a round, smooth surface, attenuated epithelium, erosion, and numerous dilated crypts. Juvenile polyposis syndrome (JPS) is an inherited, autosomal dominant disease which presents with multiple juvenile polyps in the colon and the extracolonic gastrointestinal tract. The diagnostic criteria for JPS are that the patient must present with: (1) 3-5 colonic juvenile polyps, or (2) extracolonic juvenile polyps, or (3) a single juvenile polyp in conjunction with a family history of the disease. It is caused by a mutation in SMAD4 (18q21.1) or BMPR1A (10q22.3) which result in impaired TGFbeta signal transduction. Juvenile polyps must be assessed for dysplasia as patients with JPS have a significantly increased risk of colorectal and gastric carcinoma.